Completion bonus - Successfully complete the game, and allow it to auto-save after the credits. Load the cleared saved game file repeatedly until the game begins again with all your previously purchased moves and collectibles. Note: Do not skip through the credits after loading your cleared saved game file.

View Spidey Token locations - Reach Level 10 or collect 1,000 Spidey Tokens. All Spidey Tokens will appear as red dots on the mini-map.

Use both superhero and villain strikes - As Spider-Man uses both his red and blue/black suits, his alignment meter will progress toward his good or bad side respectively. Take a look at the photo in the lower left-hand corner of the screen as well as the alignment meter in the pause menu. While the alignment picture is displaying the red and blue suit, only superheroes will aid him, and conversely while the black symbiote is displayed, only villains will help. As long as the picture is one color, it does not matter what suit you use until the meter color crosses the middle. If you maintain a very close middle ground, you can effectively utilize both the superheroes and villains (although not at the same time.) Strategize by getting both red and black points until your alignment meter is precisely in the middle. As you defeat an enemy using a certain suit, Spidey's picture will change in the lower left-hand corner of the screen. Even if you have a hero summoned, if you quickly switch to the black suit and defeat more of the enemies until the photo changes, that hero will still stay with you until you dismiss him or your special meter runs out. The same goes for villains and switching back to the red suit. The alignment affects whom you can summon, not who you have already called in. Use this strategy to defeat your enemies, get the most experience points, and unlock all the moves.

Wolverine's quiz answers - When you first meet Wolverine, he will attack, and you must fight him. He will ask a series of questions that must be answered correctly. Use the following responses to pass the quiz:

1. Richard and Mary
2. Ned Leeds
3. Battleworld
4. Daredevil
5. A Mutant
6. May Parker

Accomplish the indicated achievement to get the corresponding number of Gamerscore points:

Complete Story, Act One (50 points): Complete Act One.
Complete Story, Act Two (50 points): Complete Act Two.
Complete Web of Shadows (75 points): Complete Game.
Ultimate Spider-Man (50 points): Purchase all Upgrades.
Obsessive Spider-Man (25 points): Complete 60 Bonus Goals.
Excessive Spider-Man (15 points): Complete Half of All Optional Goals.
Max Out Spider-Man (75 points): Max Out Spider-Man.
Heroic Accumulation (25 points): Find Half of all Collectibles.
First One Hundred (15 points): Find 100 Collectibles.
50 Hit Combo - Spider Silk (10 points): Execute 50 Hit Combo "Spider Silk".
100 Hit Combo - Ownership (25 points): Execute 100 Hit Combo "Ownership".
250 Hit Combo - Neighborly (50 points): Execute 250 Hit Combo "Neighborly".
Great Power (10 points): Thwart 25 City Crimes.
Great Responsibility (25 points): Thwart 100 City Crimes.
Defeat 100 Enemies (20 points): Defeat 100 Enemies.
Defeat 500 Enemies (35 points): Defeat 500 Enemies.
No Sweat (50 points): Defeat 1000 Enemies.
The Bigger They Come... (5 points): Defeat First Tech Mech.
Eviction (5 points): Pull Tech Mech Pilot from his seat.
Encountered (5 points): Parry then Counter Attack one enemy.
Over the Counter (10 points): Parry then Counter Attack 100 enemies.
Bowling Ball (5 points): Web Swing-Kick 5 Enemies in a single pass.
Trampoline (25 points): Web-Strike Bounce 20 Enemies in succession.
Overkill (20 points): Perform all three types of attacks (Ground, Air, Wall) on a single enemy 10 times.
Ground Combo Skill (15 points): Defeat 50 Enemies using only Ground Combos.
Air Combo Skill (15 points): Defeat 50 Enemies using only Air Combos.
Wall Combo Skill (15 points): Defeat 50 Enemies using only Wall Combos.

Additionally, there are eighteen secret achievements:

Hero (20 points): Red Suit Conclusion earned.
Mary Jane and Spider-Man (20 points): Mary Jane Conclusion achieved.
Black Cat and Spider-Man (20 points): Black Cat Conclusion achieved.
Antihero (20 points): Black Suit Conclusion earned.
Bad Kitty (15 points): Black Cat defeated.
Defeat Venom, Round One (15 points): Defeated Venom once.
Grounded (15 points): Electro defeated.
Declawed (15 points): Wolverine defeated.
Defeat Symbiote Vulture (20 points): Symbiote Vulture defeated.
Defeat Symbiote Black Cat (20 points): Symbiote Black Cat defeated.
Defeat Symbiote Wolverine (20 points): Symbiote Wolverine defeated.
Defeat Symbiote Electro (20 points): Symbiote Electro defeated.
Winged (15 points): Vulture defeated.
Defeat Venom, Round Two (20 points): Defeated Venom twice.
Id (5 points): Spent time with Black Cat.
Vice (5 points): First Black Suit Choice.
Super-ego (5 points): Black Cat Spurned.
Virtue (5 points): First Red Suit Choice.