Get the lay of the land by wandering around the city,
because you can't access everything from your taxi-like
Slider call menu.
Be sure to fill out the sleeping pill prescription at
the start of the game. Follow the signs to the Pharmacy.
You'll want them to slip your superior a mickey so you
can get access to her files.
Before leaving the apartment at the start, use the fight
simulator to get the hang of the fighting system and to
build up your rank. You'll need all the help you can get
when it comes to hand-to-hand fighting.
If you're really stuck, you can buy hints at save
points. This is a useful option when the game gets
frustratingly elusive about your next goal.