At the main menu, select "Options", "Cheats", "Enter New Cheat", then enter one of the following codes to activate the corresponding cheat function.

Note: Each note or chord must be strummed.

All items - Press [Green + Red + Blue + Orange], [Green + Red + Yellow + Blue], [Green + Red + Yellow + Orange], [Green + Blue + Yellow + Orange], [Green + Red + Yellow + Blue], [Red + Yellow + Blue + Orange], [Green + Red + Yellow + Blue], [Green + Yellow + Blue + Orange], [Green + Red + Yellow + Blue], [Green + Red + Yellow + Orange], [Green + Red + Yellow + Orange], [Green + Red + Yellow + Blue], [Green + Red + Yellow + Orange]. Note: There will be no sound while entering the four note "chords". Enter the shop in Career mode to access all items. This code cannot be disabled once it is activated.

All songs in Quick Play mode - Press Yellow + Orange, Red + Blue, Red + Orange, Green + Blue, Red + Yellow, Yellow + Orange, Red + Yellow, Red + Blue, [Green + Yellow] two times, [Yellow + Blue] two times, [Yellow + Orange] two times, Yellow + Blue, Yellow, Red, Red + Yellow, Red, Yellow, Orange to unlock all songs and Co-op Encores in Quick Play mode. Note: This code cannot be disabled once it is activated.

Large Gems - Press Green, Red, Green, Yellow, Green, Blue, Green, Orange, Green, Blue, Green, Yellow, Green, Red, Green, Green + Red, Red + Yellow, Green + Red, Yellow + Blue, Green + Red, Blue + Orange, Green + Red, Yellow + Blue, Green + Red, Red + Yellow, Green + Red, Green + Yellow.

Easy Expert mode - Press Green + Red, Green + Yellow, Yellow + Blue, Red + Blue, Blue + Orange, Yellow + Orange, Red + Yellow, Red + Blue. This mode increases the size of the timing window. Note: This code cannot be used in Career mode.

No fail - Press Green + Red, Blue, Green + Red, Green + Yellow, Blue, Green + Yellow, Red + Yellow, Orange, Red + Yellow, Green + Yellow, Yellow, Green + Yellow, Green + Red. Note: This code cannot be used in Career mode.

Air guitar - Press Blue + Yellow, [Green + Yellow] two times, [Red + Blue] two times, [Red + Yellow] two times, Blue + Yellow, [Green + Yellow] two times, [Red + Blue] two times, [Red + Yellow] two times, [Green + Yellow] two times, [Red + Yellow] two times.

Hyperspeed mode - Press Orange, Blue, Orange, Yellow, Orange, Blue, Orange, Yellow. This mode makes the charts faster. There are five Hyperspeed levels. Press Green on the Hyperspeed option at the "Cheats" menu to cycle through them.

Precision mode - Press [Green + Red] three times, [Red + Yellow] two times, [Red + Blue] two times, Yellow + Blue, Yellow + Orange, Yellow + Orange, [Green + Red] three times, [Red + Yellow] two times, [Red + Blue] two times, Yellow + Blue, [Yellow + Orange] two times.

Performance mode - Press Red + Yellow, Red + Blue, Red + Orange, Red + Blue, Red + Yellow, Green + Blue, Red + Yellow, Red + Blue. This mode makes everything disappears except for the performance.

Through The Fire And The Flames song - Successfully complete Career mode on any difficulty setting to unlock "Through The Fire And The Flames" song by Dragonforce.

Bonus basses - Successfully complete the indicated task to unlock the corresponding bass:

Beach Life: Successfully complete Co-op mode on the Hard difficulty setting.

Neversoft Skateboard: Successfully complete Co-Op mode on the Expert difficulty setting with a "Five Star" rank on all songs.

PendulAxe: Successfully complete Co-op mode on the Expert difficulty setting.

The Disposed: Successfully complete Co-op mode on the Medium difficulty setting with a "Five Star" rank on all songs.

Tiki Fortune 4: Successfully complete Co-op mode on the Easy difficulty setting.

Bonus characters - Successfully complete the indicated task to unlock the corresponding character:

Lou: Successfully complete Career mode to unlock Lou for purchase at the store for $15,000. Lou comes with his skeleton guitar.

Slash: Defeat Slash in the Boss battle in Career mode to unlock him for purchase at the store for $10,000.

Tom Morello: Defeat Tom Morello in the Boss battle in Career mode to unlock him for purchase at the store for $10,000.

Bonus guitars - Successfully complete the indicated task to unlock the corresponding guitar:

Bat: Get a "Five Star" rank on all the songs on the Easy difficulty setting in Career mode.

Distant Visitor: Successfully complete Career mode on the Expert difficulty setting.

El Jefe: Get a "Five Star" rank on all the songs on the Expert difficulty setting in Career mode.

Jolly Roger: Get a "Five Star" rank on all the songs on the Medium difficulty setting in Career mode.

Moon Shot: Successfully complete Career mode on the Easy difficulty setting.

Nemesis 13: Successfully complete Co-op Career mode on the Medium difficulty setting.

Risk Assessment: Successfully complete Career mode on the Expert difficulty setting.

Radioactive: Successfully complete Co-op Career mode on the Hard difficulty setting.

Rojimbo: Successfully complete Career mode on the Hard difficulty setting.

Saint George: Successfully complete Career mode on the Medium difficulty setting.

Tiki Face: Get a "Five Star" rank on all songs on the Hard difficulty setting in Career mode.

Unfortunator: Buy Metalhead as a character for $10,000.

Battle Lou in Expert mode with Easy mode notes - When the battle with Lou starts at the end of the game on Expert mode, strum without holding any frets until you lose. At the "Game Over" screen, select "Tutorial". Pick the tutorial for Guitar Battle, and play through it until the "Lesson Complete" message appears. As soon as the next fret board appears, pause the game, and exit to return to the lesson menu. Then, press Red to return to the list of songs. The battle with Lou will be highlighted. Choose the song, and Lou's notechart will now be set to Easy mode. Note: Your notechart will still be in Expert mode, but his will be in Easy mode.

Easier songs - Before the beginning of the song (before the chords appear), move the Strum Bar Up and Down until the meter stops going down. Note: When the meter stops it will be in the red, and when the meter starts again it will be somewhere in the middle of the song.

Easy Through The Fire And Flames song - Before you use Star Power when playing the "Through The Fire And Flames" song, pause the game. Hold Select, and resume the game. By doing this, you will not miss as many notes if you are going for a "Five Star" rank.

Hammering on - Note: This can only be used if there is one note immediately following another. When you play a single green, red, yellow, or blue note and it is followed by a note that is to the right of it on the guitar controller's neck, you can hit the note without strumming the second note by keeping your finger on the first note and then pressing the next note.

Predator reference - There is a reference to the movie Predator in the song "Helicopter". After playing the song, go to the "More Stats" screen, or to Practice mode, and get to the screen where you choose what section to play. One of the sections in the song is called "Get Back To The Choppa!!!", which seems to be a reference to Arnold Schwarzenneger's line in Predator, when they are all running away from the Predator.